First things, first: under applicable United States law, the party primarily responsible for the safety of any FDA-regulated pharmaceutical product is manufacturer. Note that FDA’s role, post market-approval is to monitor; the manufacturer is supposed to do that, and more. Now, with those general rules in mind, take a look at this — it is simply a jaw-slacking visual indictment of the manufacturer of Vioxx, offered in the form of post hoc analysis — and brilliantly executed, as well (click to enlarge):
. . . .This safety record is at Merck’s feet. More, in a few moments. . . .